Longevity: mitochondrial peptide vs coenzyme

MOTS-c vs NAD+

Comparing MOTS-c and NAD+ across evidence, dosing, mechanisms, and research areas.

vs
Category
longevity
longevity
Molecular weight
2174.69 g/mol
663.43 g/mol
Half-life
~4-6 hours (estimated, limited PK data)
~30-45 minutes (IV); ~2-4 hours (SubQ)
Admin routes
subcutaneousintraperitoneal
intravenoussubcutaneousoral (NMN/NR precursors)transdermal
Research areas
Metabolic regulationExercise performanceLongevity / agingInsulin sensitivityObesityType 2 diabetesPCOSAdrenal physiology
Anti-aging / longevityMitochondrial functionNeuroprotectionAddiction recoveryDNA repairMetabolic healthInflammation modulation
Typical dosing
5000–10000 mcg · 3-5x weekly · 4-8 weeks
50000–500000 mcg · 1-2x weekly (SubQ) or monthly (IV) · Ongoing / maintenance protocol
FDA status
Not FDA-approved. Not on the 503A bulks list and not in any FDA interim category. An FDA advisory committee (PCAC) recommended it for the 503A bulks list on 2026-07-23 — for no evaluated indication; FDA has not adopted that recommendation and compounding MOTS-c is not permitted.
Not FDA-approved as drug. NAD+ precursors (NMN, NR) available OTC as dietary supplements. IV/SubQ NAD+ available through clinics and compounding pharmacies
WADA status
Not explicitly listed
Not prohibited
PubMed studies
200
1,350

This comparison is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before using any peptide or supplement.

Source this stack
MOTS-c11 vetted vendors

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NAD+10 vetted vendors

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