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TRT Off-Ramp Stack Dosage Guide

Kisspeptin-10 + Gonadotropin + BPC-157

Come off TRT gradually and restart natural production Kisspeptin 20-50 mcg 3x/week; Gonadotropin 100-250 mcg/day for 2-4 weeks

Last updated · 2026-04-27
Male Hormonal Health aka Kisspeptin-10 + Gonadotropin + BPC-157 aka post-TRT peptide stack aka coming off TRT stack
Promising

Reasonable pairing with mechanistic rationale; widely used in community protocols.

Buy this stack

Cheapest Split $31.99 across 1 vendor
CompoundVendorSizePrice
BPC-157 Particle Peptides 5 mg $31.99

Missing vendor data for: Kisspeptin-10, Gonadotropin

Components

Kisspeptin

Endogenous ligand for GPR54 (KISS1R). Activates hypothalamic GnRH neurons, triggering pulsatile GnRH release and downstream LH/FSH secretion. Master regulator of reproductive axis initiation and maintenance.

Half-life: KP-54: ~28 minutes (IV); KP-10: ~4 minutes (IV)

Gonadotropin

Compound page not yet published

BPC-157

Upregulates growth hormone receptors, modulates nitric oxide system (NO/NOS), promotes angiogenesis, activates FAK-paxillin pathway, modulates dopaminergic and serotonergic systems

Half-life: ~4 hours (stable in gastric juice — unique among peptides)

Come off TRT gradually and restart natural production

Dosing notes

Kisspeptin 20-50 mcg 3x/week; Gonadotropin 100-250 mcg/day for 2-4 weeks

Adapted from community peptide protocols. Reference compositions and dosing draw on The Ultimate Peptides Bible (Ralston, 2026) and widely circulated stacking conventions. See methodology for our content sourcing approach.

This content is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare provider before using any peptide or supplement.

Where to buy BPC-157
BPC-15712 vetted vendors
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