Ask VialBase
longevity

Epithalon

Also known as: Epitalon, Epithalone, Ala-Glu-Asp-Gly
FDA: Not FDA-approved WADA: Not listed

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Russian gerontologist Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It is the synthetic version of epithalamin, a peptide naturally produced by the pineal gland. Epithalon's primary mechanism is the activation of telomerase (specifically hTERT -- the catalytic subunit), leading to telomere elongation in somatic cells. In addition to telomere effects, it regulates pineal gland function, melatonin synthesis, and exhibits antioxidant properties. Research spans over 35 years, primarily in Russian institutions, with recent international validation of its telomerase-activating properties. For educational purposes only. Not medical

This content is for educational and research purposes only. VialBase does not provide medical advice. Consult a healthcare professional before using any peptide.

Molecular weight 390.35 Da
Half-life ~30 minutes estimated
CAS number —
Route Subcutaneous · Intravenous subcutaneous preferred
02

Mechanism

Activates telomerase (hTERT), potentially lengthening telomeres and extending cellular lifespan; regulates melatonin synthesis via pineal gland modulation; antioxidant properties

03

Dosing

DOSE RANGE 5000–10000 mcg
FREQUENCY 1x daily
CYCLE LENGTH 10-20 days, 2-3x per year

Short intensive cycles rather than continuous use. Based on Khavinson protocol. Some protocols use 5-10 mg SubQ daily for 10 days, repeated 2-3x per year.

04

Research summary

Study Type Year Key Finding
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy In vitro 2025 Epitalon enhanced wound healing in diabetic retinopathy cell model
Epitalon dose-dependent telomere extension through hTERT and telomerase upregulation; ALT activation in cancer cells In vitro (multiple cell lines) 2025 Dose-dependent telomere length extension in normal epithelial and fibroblast cells
Khavinson Epithalon/Epithalamin Longevity Research Overview Summary of longitudinal research program 2002-2020 15+ years of human studies with epithalamin/epitalon in elderly patients
05

Stacking & interactions

Longevity stack — telomere + collagen/tissue repair

Comprehensive anti-aging — telomere + mitochondrial/sirtuin

Longevity + cognitive — cellular age reversal + neuroplasticity

Tissue repair + cellular longevity

06

Sourcing

Current prices

Updated today

10mg

20mg

Only vendor stocking this size on the VialBase roster.

25mg

Only vendor stocking this size on the VialBase roster.

50mg

Size unspecified

Only vendor stocking this size on the VialBase roster.

Stocks this compound Third-party tested Public COAs Positive rep

Save 20% with code VIALBASE at checkout

Stocks this compound Third-party tested Public COAs Positive rep
Stocks this compound Third-party tested Public COAs Positive rep

Save 15% with code VIALBASE at checkout

VialBase may earn a commission on purchases through partner links — never at additional cost to you. Full disclosure.

Also vetted at
What bloodwork do I need?

Reference ranges are general guidelines. Consult your physician for interpretation.

PRE-CYCLE
  • CMP
  • CBC
  • Thyroid Panel (TSH, Free T3, Free T4)
DURING CYCLE
  • Thyroid Panel
POST-CYCLE
  • Thyroid Panel
  • CMP
Safety & Regulatory Status
FDA STATUS Not FDA-approved
WADA STATUS Not listed

Regulatory status for Epithalon may change. Verify current status with your jurisdiction before use. This is not legal or medical advice.

References

  1. Gatta M, Dovizio M, Milillo C, et al.. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. Stem Cell Rev Rep (2025). PMID: 40493162
  2. Various. Epitalon dose-dependent telomere extension through hTERT and telomerase upregulation; ALT activation in cancer cells. Biogerontology (2025). PMID: 40908429
  3. Khavinson VK, Morozov VG. Khavinson Epithalon/Epithalamin Longevity Research Overview. Various (Neuro Endocrinol Lett, other Russian journals) (2002-2020).