Ask VialBase
Preclinical (in vivo + in vitro, mice) · PMID 41952615

Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice — VialBase Research

KP-10 enhanced P4 and E2 hormone synthesis and secretion

Last updated · 2026 · Suocheng W, Linglong X, Jingshuang G, Zhenya G, Yuan C · Molecular Reproduction and Development
Key findings
  • KP-10 enhanced P4 and E2 hormone synthesis and secretion
  • Promoted proliferation and inhibited apoptosis of follicular granulosa cells
  • Facilitated secondary follicle development
  • Optimal efficacy at 10 mcg/g dose
  • Mechanism: activation of PI3K/AKT/ERK signaling pathway
  • First comprehensive in-vivo/in-vitro study of KP-10 effects on murine reproduction

PMID 41952615 — KP-10 Promotes Ovarian Function in Mice

Compound: Kisspeptin Citation: Suocheng W et al. Mol Reprod Dev. 2026;93(4):e70093. doi:10.1002/mrd.70093

Summary

Comprehensive in-vivo and in-vitro study examining how KP-10 modulates hormone secretion, follicular granulosa cell function, and ovarian follicle development in mice.

Key Findings

  • Hormone secretion: KP-10 enhanced progesterone (P4) and estradiol (E2) synthesis
  • Granulosa cells: Promoted proliferation, inhibited apoptosis, modulated autophagy
  • Follicle development: Facilitated secondary follicle growth
  • Dose optimization: 10 mcg/g produced best efficacy
  • Signaling: PI3K/AKT/ERK pathway activation mediates effects
  • Fecundity: Improved reproductive outcomes in treated mice

Relevance to Kisspeptin

Provides mechanistic detail for kisspeptin’s direct ovarian effects beyond hypothalamic GnRH regulation. Suggests kisspeptin acts at multiple levels of the reproductive axis — both centrally (hypothalamus) and peripherally (ovary).

PubMed

See Also

View on PubMed · PMID 41952615 →