A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review — VialBase Research
Ipamorelin identified as one of the most popular growth hormone secretagogues in sport
- Ipamorelin identified as one of the most popular growth hormone secretagogues in sport
- Receptor selectivity (GH release without cortisol/prolactin) is key selling point
- Clinical evidence for sport performance enhancement is limited
- Pharmacological profile includes enhanced stability and selectivity
- Growing popularity among recreational athletes despite limited evidence
Summary
Critical review documenting the evolution of pharmacological enhancement in sport from AAS to peptides. Identifies ipamorelin as a leading growth hormone secretagogue used by athletes and bodybuilders, promoted for muscle growth, fat metabolism, recovery, and anti-inflammatory effects.
Key Findings
- Ipamorelin’s selectivity (GH release without cortisol/prolactin elevation) makes it preferred among athletes
- Enhanced receptor specificity compared to GHRP-6 and GHRP-2 is its primary marketing advantage
- Despite popularity, clinical evidence for sports enhancement is insufficient
- Significant regulatory gaps allow distribution with minimal oversight
Relevance to Ipamorelin
Contextualizes ipamorelin’s position in the sports/bodybuilding peptide landscape. Confirms it is one of the most popular GHRPs but highlights the evidence gap between marketing claims and clinical proof for athletic performance. Also relevant to CJC-1295 — both are frequently discussed together.
Citation
Coutinho LFD, et al. J Sports Med Phys Fitness. 2026 Mar 25. PMID: 41880199
See Also
- Parent compound: Ipamorelin
- CJC-1295
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