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In vitro · PMID 41824632

Thymosin alpha1-induced secretion of the IL-15/RA complex by THP-1-derived dendritic cells restrains HIV latency in vitro — VialBase Research

Ta1 induced IL-15/IL-15RA complex secretion from THP-1-derived dendritic cells

Last updated · 2026 · Chen C, Xun J, Wang J, et al. · Virulence
Key findings
  • Ta1 induced IL-15/IL-15RA complex secretion from THP-1-derived dendritic cells
  • This secretion restrained HIV latency in co-culture models
  • Suggests Ta1 role in 'shock and kill' HIV cure strategies

Ta1 Restrains HIV Latency via IL-15/RA from DCs (PMID: 41824632)

Study Design

  • In vitro model using THP-1-derived dendritic cells
  • Co-culture with HIV-latent cell models
  • Measured IL-15/IL-15RA complex secretion

Key Results

  • Ta1 stimulated dendritic cells to secrete IL-15/IL-15RA complex
  • This complex restrained HIV latency in co-culture
  • Mechanism links Ta1’s known DC-activating properties to a novel HIV application

Relevance

Opens a potential role for Thymosin-Alpha-1 in HIV cure research (latency reversal). The IL-15 axis is a known target in HIV functional cure strategies, and Ta1 provides a way to stimulate endogenous IL-15 production via dendritic cell activation.

See Also

View on PubMed · PMID 41824632 →