Research article · PMID 41462712
GHK Tripeptide Gene Regulation and Biological Activity — VialBase Research
GHK modulates expression of thousands of human genes
Last updated · 2025 · Multiple authors · Various
Key findings
- GHK modulates expression of thousands of human genes
- Broad anti-aging gene expression signature
- Distinct activity profile from copper-bound GHK-Cu form
PMID 41462712 — GHK Gene Regulation
Compound: GHK Citation: PubMed
Summary
Research exploring GHK tripeptide’s gene regulatory activity. Contributes to understanding of GHK’s broad genomic effects across tissue repair, anti-inflammatory, and anti-aging gene networks.
Relevance to GHK
GHK’s ability to modulate expression of ~4,000 human genes (~6% of genome) is remarkable for a 3-amino-acid peptide. This genomic breadth distinguishes GHK from peptides with single-target mechanisms and suggests wide-ranging therapeutic potential.