Preclinical pharmacology (biodistribution / ligand-receptor) · PMID 34726863
Investigation of ligand-receptor interaction and biodistribution of a drug containing cattle retina polypeptides — VialBase Research
Gives Retinalamin an unusual PK/target-engagement data point; cited as mechanism pathway 3 on the compound page.
Last updated · 2021 · Verlov NA et al. · Vestn Oftalmol
Key findings
- Characterized ligand-receptor interaction and tissue biodistribution of the cattle-retina polypeptide drug (Retinalamin)
- Rare pharmacokinetic/target-engagement evidence for a Khavinson bioregulator, which usually rests on phenomenological outcomes
- Supports that the peptide complex reaches and engages retinal tissue
Retinalamin biodistribution & target engagement (PMID: 34726863)
Summary
This study investigated the ligand–receptor interaction and biodistribution of a drug containing cattle retina polypeptides (Retinalamin), providing pharmacokinetic/target-engagement evidence that the peptide complex reaches and interacts with retinal tissue.
Relevance
Most Khavinson-bioregulator evidence is phenomenological (outcome-only). This study is notable for Retinalamin because it addresses how the drug distributes and engages its target — a gap in the wider bioregulator literature.
See Also
- Parent compound: Retinalamin