Glossary
Loading Dose
An initial higher dose administered at the start of a protocol to rapidly achieve therapeutic concentration, before transitioning to a lower maintenance dose.
Also known as:
front-load loading phase
A loading dose compensates for the time it takes a compound to accumulate to effective levels in the body. Rather than waiting multiple half-lives for steady-state concentration to build, a larger initial dose saturates the system faster. This approach is used with some peptide protocols and is common with TB-500.
Not all peptides require or benefit from a loading dose — it depends on the compound’s half-life, mechanism, and the urgency of reaching therapeutic levels. Always refer to compound-specific protocols rather than applying a loading dose universally.