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Thymalin

FDA: not-FDA-approved
Last updated · 2026-04-12

Thymalin is a thymus bioregulator peptide complex that restores thymus function, supports immune cell education, and modulates immune overactivation. One of the oldest peptide bioregulators with a strong safety record, it is commonly prescribed to elderly patients for immune revitalization and appears in nearly all cancer support and immune stacks. Clinical data on thymic and pineal peptide bioregulators report increased survival in elderly patients (PMID: 14523363). Restores thymus function and supports immune cell education. Targets thymus output and lymphocyte maturation. Modulates immune overactivation and neuroinflammatory markers. Rebuilds immune-endocrine stability and circadian rhythm. Supports T3/T4 conversion and immune-circadian coordination. Improves epigenetic

This content is for educational and research purposes only. VialBase does not provide medical advice. Consult a healthcare professional before using any peptide.

Molecular weight —
Half-life —
CAS number 63958-90-7
Route —
Where to buy Thymalin →Particle Peptides
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Research summary

Study Type Year Key Finding
[Geroprotective effect of thymalin and epithalamin]. Russian-language clinical review of a long-term observational geroprotection cohort (English abstract only) 2002 Reports clinical assessment of Thymalin and Epithalamin in 266 elderly and older persons observed over 6-8 years, with the bioregulators applied only during the first 2-3 years
Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells. Laboratory study of human hematopoietic stem cells (surface-marker expression) 2020 Thymalin is described as a polypeptide complex isolated from thymus that regulates immune system function and increases functional activity of T lymphocytes
Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. In-vitro cell-line study (human THP-1 monocyte/macrophage line) 2022 In-vitro only: all work was performed in the human leukemia monocytic THP-1 cell line, differentiated into macrophages with PMA, plus LPS-activated HUVEC endothelial layers
The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19. Molecular modeling and bioinformatics analysis with in-vitro validation in human peripheral blood mononuclear cells 2023 Studies the isolated KE and EW dipeptides described as the active substances of Thymalin, not the Thymalin preparation alone

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10mg

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20mg

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25mg

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Reference ranges are general guidelines. Consult your physician for interpretation.

PRE-CYCLE
  • CMP
  • CBC with differential
  • CRP
DURING CYCLE
  • CBC with differential
POST-CYCLE
  • CMP
  • CBC with differential
Safety & Regulatory Status
FDA STATUS not-FDA-approved

Regulatory status for Thymalin may change. Verify current status with your jurisdiction before use. This is not legal or medical advice.

Frequently Asked Questions

What is Thymalin?
Thymalin is a thymus bioregulator peptide complex that restores thymus function, supports immune cell education, and modulates immune overactivation.
How does Thymalin work?
Restores thymus function and supports immune cell education. Targets thymus output and lymphocyte maturation. Modulates immune overactivation and neuroinflammatory markers.
How is Thymalin dosed?
Standard: 10 mg/day for 5-10 days (most common cycle); Maintenance: 10 mg/day for 5 days/month; monthly pulse dosing; Low-dose: 1 mg 2-3x/week; Route: SubQ injection; Cycling: Short 10-20 day cycles; repeat quarterly or seasonally. These figures reflect commonly cited research protocols, not medical advice — consult a clinician.
Is Thymalin FDA-approved?
Thymalin is not FDA-approved. Not FDA-approved in the United States; Widely used in Russia and Eastern Europe with decades of clinical history; Available through international pharmacies and research suppliers; Part of the Khavinson peptide bioregulator family.

References

  1. Khavinson VKh, Morozov VG. [Geroprotective effect of thymalin and epithalamin].. Advances in gerontology = Uspekhi gerontologii (2002). PMID: 12577695
  2. Khavinson VK, Linkova NS, Kvetnoy IM, et al.. Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells.. Bulletin of experimental biology and medicine (2020). PMID: 33237528
  3. Avolio F, Martinotti S, Khavinson VK, et al.. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.. International journal of molecular sciences (2022). PMID: 35408963
  4. Linkova N, Khavinson V, Diatlova A, et al.. The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19.. International journal of molecular sciences (2023). PMID: 37686182