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NSI-189

FDA: research-only
Last updated · 2026-04-12

NSI-189 is a neurogenic compound that stimulates hippocampal neurogenesis and provides mood-lifting effects. It works on different aspects of neurogenesis and mood regulation than other cognitive peptides, making it especially effective in trauma-related depression. Boosts neurogenesis with a focus on hippocampal growth. Reduces neuroinflammation. Adds a mood-lifting neurogenic edge over time. Works on different aspects of neurogenesis and mood regulation than Dihexa or Cerebrolysin, especially effective in trauma-related depression. - Hippocampal neurogenesis stimulation - Mood resilience and anti-depression effects - Brain fog clearing - Cognitive enhancement - Trauma-related depression support - Neuroinflammation reduction - Standard: 20-40 mg oral daily -

This content is for educational and research purposes only. VialBase does not provide medical advice. Consult a healthcare professional before using any peptide.

Molecular weight —
Half-life —
CAS number 1270138-40-3
Route —
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What bloodwork do I need?

Reference ranges are general guidelines. Consult your physician for interpretation.

PRE-CYCLE
  • CMP
  • CBC
  • Lipid Panel
DURING CYCLE
  • CMP
POST-CYCLE
  • CMP
  • CBC
Safety & Regulatory Status
FDA STATUS research-only

Regulatory status for NSI-189 may change. Verify current status with your jurisdiction before use. This is not legal or medical advice.

Frequently Asked Questions

What is NSI-189?
NSI-189 is a neurogenic compound that stimulates hippocampal neurogenesis and provides mood-lifting effects. It works on different aspects of neurogenesis and mood regulation than other cognitive peptides, making it especially effective in trauma-related depression.
How does NSI-189 work?
Boosts neurogenesis with a focus on hippocampal growth. Reduces neuroinflammation. Adds a mood-lifting neurogenic edge over time.
How is NSI-189 dosed?
Standard: 20-40 mg oral daily; Cycle: 4-6 weeks; Microdose: 2-4 mg before therapy sessions; Route: Oral. These figures reflect commonly cited research protocols, not medical advice — consult a clinician.
Is NSI-189 FDA-approved?
NSI-189 is a research-only compound and is not FDA-approved. Research-only — not FDA-approved; Was in clinical trials for depression; Available through research chemical suppliers.