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Melanotan I

FDA: FDA-approved
Last updated · 2026-04-12

Melanotan I is a synthetic analog of alpha-MSH that stimulates melanin production for sunless tanning and potential photoprotection. Marketed pharmaceutically as afamelanotide, it is the more selective and safer cousin of Melanotan-II. Synthetic analog of alpha-MSH that stimulates melanin production by binding to melanocortin-1 receptors (MC1R) in skin cells. Enhances tanning response and may reduce UV-induced skin damage through increased melanin. More selective for MC1R than Melanotan-II, which also activates MC3R/MC4R (sexual arousal pathways). - Sunless tanning and skin pigmentation - Potential photoprotection against UV damage - Erythropoietic protoporphyria (EPP) treatment - Reduced need for UV exposure to achieve tan

This content is for educational and research purposes only. VialBase does not provide medical advice. Consult a healthcare professional before using any peptide.

Molecular weight —
Half-life —
CAS number 75921-69-6
Route —
Where to buy Melanotan I →BioLongevity Labs · save 15% code VIALBASE
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10mg

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Stocks this compound Third-party tested Public COAs
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Save 20% with code VIALBASE at checkout

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What bloodwork do I need?

Reference ranges are general guidelines. Consult your physician for interpretation.

PRE-CYCLE
  • CMP
  • CBC
  • Dermatologic exam (mole check)
DURING CYCLE
  • Visual mole monitoring
POST-CYCLE
  • CMP
  • Dermatologic exam
Safety & Regulatory Status
FDA STATUS FDA-approved

Regulatory status for Melanotan I may change. Verify current status with your jurisdiction before use. This is not legal or medical advice.

Frequently Asked Questions

What is Melanotan I?
Melanotan I is a synthetic analog of alpha-MSH that stimulates melanin production for sunless tanning and potential photoprotection. Marketed pharmaceutically as afamelanotide, it is the more selective and safer cousin of Melanotan-II.
How does Melanotan I work?
Synthetic analog of alpha-MSH that stimulates melanin production by binding to melanocortin-1 receptors (MC1R) in skin cells. Enhances tanning response and may reduce UV-induced skin damage through increased melanin. More selective for MC1R than Melanotan-II, which also activates MC3R/MC4R (sexual arousal pathways).
How is Melanotan I dosed?
Cycled depending on skin type and tanning response; Route: SubQ injection; Pharmaceutical version (afamelanotide) uses implant delivery. These figures reflect commonly cited research protocols, not medical advice — consult a clinician.
Is Melanotan I FDA-approved?
Melanotan I is FDA-approved. FDA-approved as afamelanotide (Scenesse) for EPP treatment; Off-label use for tanning; Prescription required for pharmaceutical form.