Ask VialBase
longevity

Humanin

FDA: research-only

Humanin is a mitochondrial-derived peptide (like MOTS-c) that activates AMPK (with downstream mitochondrial-biogenesis effects), restoring energy production pathways; a specific humanin→PGC-1alpha link is not established in primary literature [PMID unverified — flagged 2026-06-19] (AMPK/insulin-sensitivity role supported by PMID: 32245619). It represents a class of endogenous peptides encoded within mitochondrial DNA that regulate cellular survival and metabolism. Activates AMPK (with downstream mitochondrial-biogenesis effects), restoring energy production pathways; a specific humanin→PGC-1alpha link is not established in primary literature [PMID unverified — flagged 2026-06-19]. The AMPK/insulin-sensitivity role is supported by primary literature (PMID: 32245619). Promotes mitochondrial biogenesis and cellular energy restoration (PMID: 29432738).

This content is for educational and research purposes only. VialBase does not provide medical advice. Consult a healthcare professional before using any peptide.

Molecular weight —
Half-life —
CAS number 330936-69-1
Route —
02

Sourcing

Current prices

Updated today

5mg

Only vendor stocking this size on the VialBase roster.

10mg

Only vendor stocking this size on the VialBase roster.

Stocks this compound Third-party tested Public COAs

Save 15% with code vialbase15 at checkout

Stocks this compound Third-party tested Public COAs

VialBase may earn a commission on purchases through partner links — never at additional cost to you. Full disclosure.

What bloodwork do I need?

Reference ranges are general guidelines. Consult your physician for interpretation.

PRE-CYCLE
  • CMP
  • CBC
  • Fasting Glucose
  • Fasting Insulin
DURING CYCLE
  • Fasting Glucose
  • Fasting Insulin
POST-CYCLE
  • CMP
  • Fasting Glucose
Safety & Regulatory Status
FDA STATUS research-only

Regulatory status for Humanin may change. Verify current status with your jurisdiction before use. This is not legal or medical advice.

Frequently Asked Questions

What is Humanin?
Humanin is a mitochondrial-derived peptide (like MOTS-c) that activates AMPK, restoring energy production pathways; a specific humanin-to-PGC-1alpha link is not established in primary literature [PMID unverified — flagged 2026-06-19]. It represents a class of endogenous peptides encoded within mitochondrial DNA that regulate cellular survival and metabolism.
How does Humanin work?
Activates AMPK, restoring energy production pathways; a specific humanin-to-PGC-1alpha link is not established in primary literature [PMID unverified — flagged 2026-06-19]. Promotes mitochondrial biogenesis and cellular energy restoration. Acts as a cytoprotective peptide, protecting cells from apoptosis and oxidative stress.
How is Humanin dosed?
Mentioned as part of MOTS-c stack category; Specific dosing protocols not well established in the book; Route: Research protocols vary. These figures reflect commonly cited research protocols, not medical advice — consult a clinician.
Is Humanin FDA-approved?
Humanin is a research-only compound and is not FDA-approved. Research-only — not FDA-approved; Early-stage research compound; Not widely available commercially.