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Dihexa

FDA: research-only
Last updated · 2026-04-12

Dihexa is a nootropic peptide derived from angiotensin IV that enhances synaptogenesis and supports BDNF signaling pathways. It is considered one of the most potent cognitive enhancers in the peptide space, promoting long-term synaptic connectivity critical for learning and memory. Enhances synaptogenesis (formation of new synaptic connections) and may support BDNF signaling pathways. Promotes long-term synaptic connectivity critical for learning and memory. Stimulates neurotrophic activity and neurogenesis. Supports hippocampal function and cognitive plasticity. Evidence to date is preclinical — angiotensin-IV-analog studies in rodents and cell systems showing synaptogenesis via the hepatocyte growth factor (HGF)/c-Met system; there are no human clinical

This content is for educational and research purposes only. VialBase does not provide medical advice. Consult a healthcare professional before using any peptide.

Molecular weight —
Half-life —
CAS number 1401708-83-5
Route —
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Stacks containing Dihexa

Brain Blitz

Semax + Dihexa + Cerebrolysin

Flow State Induction

Semax Amidate + Dihexa + Selank

28-day resets featuring Dihexa

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Safety & Regulatory Status
FDA STATUS research-only

Regulatory status for Dihexa may change. Verify current status with your jurisdiction before use. This is not legal or medical advice.

Frequently Asked Questions

What is Dihexa?
Dihexa is a nootropic peptide derived from angiotensin IV that enhances synaptogenesis and supports BDNF signaling pathways. It is considered one of the most potent cognitive enhancers in the peptide space, promoting long-term synaptic connectivity critical for learning and memory.
How does Dihexa work?
Enhances synaptogenesis (formation of new synaptic connections) and may support BDNF signaling pathways. Promotes long-term synaptic connectivity critical for learning and memory. Stimulates neurotrophic activity and neurogenesis.
How is Dihexa dosed?
Oral: 4-8 mg/day (most common); 5-20 mg in research protocols; Cycle: 10 days on, 5 off; or 3-5x/week; Route: Oral (primary); SubQ also noted. These figures reflect commonly cited research protocols, not medical advice — consult a clinician.
Is Dihexa FDA-approved?
Dihexa is a research-only compound and is not FDA-approved. Research compound — not FDA-approved for human use; Not approved in any jurisdiction for clinical use; Available through research chemical suppliers.